What is upper tract transitional cell carcinoma?

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Can you survive transitional cell carcinoma?

Transitional cell carcinoma of the renal pelvis, accounting for only 7% of all kidney tumors, and transitional cell cancer of the ureter, accounting for only 1 of every 25 upper urinary tract tumors, are curable in more than 90% of patients if they are superficial and confined to the renal pelvis or ureter.

Is transitional cell carcinoma fatal?

Renal UC is uniformly fatal unless it is treated. In a multicenter study of 1363 patients with upper urinary tract urothelial carcinoma who were treated with radical nephroureterectomy, the 5-year cancer-specific survival probability was approximately 73%.

What does transitional cell carcinoma mean?

Transitional cell cancer (TCC) is a rare type of kidney cancer. It starts in cells called transitional cells. There are many different types of cells in the body, each with a particular job to do. Transitional cells are able to change shape and stretch.

How long do you live with transitional cell carcinoma?

Overall survival and cancer-specific survival

For the entire cohort, there were 986 (51.6%) patients who died and 704 (36.9%) patients who died from primary transitional cell carcinoma of the ureter. The median overall survival (OS) was 46 months, and the 5-year OS rate was 41.8%.

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How aggressive is transitional cell carcinoma?

Transitional Cell Carcinoma: An Aggressive Cancer. Transitional cell carcinoma affects the transitional cells of the urinary system and accounts for an overwhelming majority of bladder cancer diagnoses. This cancer may spread rapidly, affecting other organs and becoming life-threatening in some cases.

How serious is transitional cell carcinoma?

If it’s high grade, it’s more likely to spread to deeper layers of your bladder, other areas of your body, and your lymph nodes. It’s also likely to come back after treatment. High-grade TCC is the type of bladder cancer that is more likely to be life-threatening.

How does transitional cell carcinoma affect the body?

Cancer that begins in the transitional cells is the most common type of cancer that develops in the renal pelvis and ureter. In some cases, transitional cell cancer metastasizes, which means that cancer from one organ or part of the body spreads to another organ or part of the body.

Where does transitional cell carcinoma metastasis?

Transitional cell carcinoma (TCC) of the bladder commonly metastasizes to the pelvic lymph nodes, lungs, liver, bones, adrenals, or brain. Unusual sites include the heart, kidney, spleen, pancreas, and reproductive system.

What is high grade urothelial carcinoma?

Low-grade papillary urothelial carcinoma: These tumors tend to grow slowly, but they can come back after treatment. High-grade papillary urothelial carcinoma: These tumors grow more quickly and are more likely to spread.

What causes TCC?

The exact cause of upper urinary tract TCC is not known; however, several risk factors have been identified. Workers in the chemical, petrochemical, aniline dye, and plastics industries, as well as those exposed to coal, coke, tar, and asphalt, are at increased risk for renal pelvis and ureteral tumors.

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What is transitional cell carcinoma of the kidney?

Renal transitional cell carcinoma (TCC), or renal urothelial carcinoma (UC), is a malignant tumor arising from the transitional (urothelial) epithelial cells lining the urinary tract from the renal calyces to the ureteral orifice (see the image below). UC is the most common tumor of the renal pelvis.