What does tamoxifen do to the body?
Tamoxifen is a type of hormonal therapy known as a selective estrogen receptor modulator (SERM). The drug attaches to hormone receptors (specific proteins) in breast cancer cells. Once the medication is inside the cells, it stops the cancer from accessing the hormones they need to multiply and grow.
What happens after taking tamoxifen for 10 years?
Tamoxifen can have side effects, including hot flashes, fatigue, and an increased risk of blood clots and endometrial cancer. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported.
How effective is tamoxifen?
Tamoxifen can: reduce the risk of breast cancer coming back by 40% to 50% in postmenopausal women and by 30% to 50% in premenopausal women. reduce the risk of a new cancer developing in the other breast by about 50% shrink large, hormone-receptor-positive breast cancers before surgery.
How long do you take Zoladex for breast cancer?
How long will I be given goserelin for? If you have primary breast cancer, goserelin is usually given for up to five years or sometimes longer. If you have secondary breast cancer, you will be given goserelin for as long as it keeps the cancer under control.
What foods should not be eaten when taking tamoxifen?
You certainly don’t want to take a medication to reduce breast cancer risk, only to eat or drink something that renders the tamoxifen less effective. The foods of most concern for women taking tamoxifen are grapefruit and tangerines. Grapefruit is well-known to interfere with numerous medications.
Can you take vitamin D with tamoxifen?
No interactions were found between tamoxifen and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Is it worth taking tamoxifen for 10 years?
A recent study published in the British Journal of Medicine indicated clear evidence that 10 years of tamoxifen therapy does reduce local recurrence and improve breast cancer-free survival. However, it also reported that extended use (10 years rather than five) was linked with a two-fold increase in endometrial cancer.
Is tamoxifen safe long term?
While the study confirmed a strong association between long-term tamoxifen therapy and an increased risk of ER-negative second cancer, it does not suggest that breast cancer survivors should stop taking hormone therapy to prevent a second cancer, Li said.
How long is tamoxifen in your system?
How long does tamoxifen stay in your system? Tamoxifen stays active in the body for about 1 to 2 weeks after your last dose but can take about 3 months to completely leave your system.
How bad is tamoxifen?
Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones.
Is 10 mg of tamoxifen as effective as 20mg?
(18) demonstrate that lower doses of tamoxifen (5 mg/day and 10 mg/day) are less effective than the 20 mg/day dose at reducing normal breast cell proliferation, as measured by mitotic index. These data argue against using lower doses of tamoxifen for breast cancer prevention.
Does tamoxifen affect sleep?
Background: Insomnia is a frequent adverse effect reported by women taking tamoxifen, an estradiol receptor-antagonist, for breast cancer.