Who can administer intrathecal chemotherapy?
5.1 Prescribing: Registered medical practitioners of ST4 level and above, staff in a nonconsultant career grade and consultants, who are currently named on the register, can prescribe intrathecal chemotherapy.
Who can prescribe intrathecal drugs?
Intrathecal chemotherapy should be approved and prescribed only by Consultant Haematologists, Staff Grade or Associate Specialist Haematologists who are authorised by the Lead Clinician for this specific area of clinical practice (Appendix 1).
What process should be followed when administering intrathecal chemotherapy?
Intrathecal chemotherapy is administered during a procedure called a lumbar puncture or through an ommaya reservoir (shunt). Prior to having IT chemotherapy, you will have your labwork done. You need to have a sufficient platelet count to ensure that your blood will clot at the site after the procedure.
How often is intrathecal chemotherapy given?
For treatment, in general, you’ll likely get two doses a week at first and then one weekly or monthly. The biologic rituximab, sometimes in combination with methotrexate, is used for some types of lymphoma.
Is intrathecal chemotherapy painful?
After intrathecal chemotherapy
Having this treatment is not usually painful. Some people may find it uncomfortable or have a headache for a few hours afterwards. Tell your doctor or nurse if you have a headache, as they can give you mild painkillers to help.
Is intrathecal chemotherapy sterile?
Sterility tests showed no bacterial or fungal culture in our preparations stored up to 4 days prior inoculation. Conclusions This study ensures us that our process provides sterile intrathecal methotrexate, hydrocortisone and aracytine preparation.
Why is methotrexate given intrathecally?
Methotrexate is a chemotherapy drug that is used to treat certain types of cancer and leukaemia. When given intrathecally, it prevents leukaemia cells entering the cerebrospinal fluid (CSF) around the spine and brain. It is also used to treat leukaemia found in the CSF.
What drugs can you give intrathecally?
Currently there are only three medications approved by the US Food and Drug Administration (FDA) for use via the intrathecal route, ie, morphine, ziconotide, and baclofen. Morphine targets opioid receptors within the dorsal horn.
What happens if vincristine is given intrathecally?
Vincristine has a high neurotoxicity level. If given intrathecally by accident, it can cause ascending radiculomyeloencephalopathy, which is almost always fatal. The authors report a rare case in which vincristine was accidentally injected intrathecally into a 32-year-old man.
What drugs are used in chemotherapy?
Many different kinds of chemotherapy or chemo drugs are used to treat cancer – either alone or in combination with other drugs or treatments.
Examples of alkylating agents include:
How do you give intrathecal?
- You will sit and bend over or lie on your side.
- Your back will be carefully cleaned.
- The anesthesiologist will numb your skin. …
- Once your skin is numb, the anesthesiologist places a special needle into your back and into the spinal space. …
- He or she will inject the medicine into this space.
Where is intrathecal injection given?
Intrathecal drug administration is the introduction of a therapeutic substance into the cerebrospinal fluid by injection into the subarachnoid space of the spinal cord to bypass the blood-brain barrier. The main indications are for anesthesia and pain management.