Is there a role for IGF 1 in the development of second primary cancers?

The IGFFamily


People may also misuse or abuse IGF-1. The side effects of IGF-1 may be similar to those of other growth hormones. These include overgrowth of body tissues, known as acromegaly, and damage to the joints, liver, and heart. IGF-1 can cause your blood glucose levels to drop.

What health problems are linked to high amounts of IGF-1?

Increased secretion of GH and IGF-1 leads to abnormal glucose regulation, causing diabetes mellitus. A defect in lipid metabolism is also observed in some patients with acromegaly. The high level of IGF-1 in acromegaly is related to an increased risk of some cancers, particularly colon cancer and thyroid cancer.

Does IGF-1 affect hormones?

In conclusion, IGF-1 is an important growth hormone, mediating the anabolic and linear growth promoting effect of pituitary GH protein.

What causes increased IGF?

Elevated IGF-1 and GH may indicate acromegaly in adults. Increased levels of GH and IGF-1 are normal during puberty and pregnancy; during the latter, serum IGF-1 increases on average almost 2-fold. Otherwise, increased levels are most frequently due to pituitary tumors (usually benign).

Does IGF-1 cause weight gain?

Generally, you will accomplish much more in terms of muscle density and size at a normal genetic level. In other words, the weight gain that you will experience from the use of IGF-1 is not due to retention of water. The weight gain is caused by actual muscle growth and is a long term effect.

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Does fasting increase or decrease IGF-1?

Fasting caused an increase in serum GH levels, no significant change in serum GHBP levels, and a decrease in serum IGF-1 levels. In the growth plate, both GH receptor mRNA levels and IGF-1 mRNA levels were increased by fasting.

Does IGF-1 build muscle?

In addition to a direct anabolic effect on skeletal muscle—for example, the production of more protein—IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells). Results of animal studies suggest that this process is obligatory for muscle hypertrophy to proceed.

How do I lower my IGF-1?

The combination of a low-fat diet and exercise program is known to reduce IGF levels. Barnard et al. [13, 14] showed a decrease in the serum concentration of IGF-I and an increase in IGFBP-1 with the implementation of a low-fat diet and exercise program.

What should my IGF-1 levels be?

Low IGF-1 is considered by most to be between 84–100 µ/l and numerous studies recommend that raising IGF-1 to high normal range reverses Chronic Medical Diseases (CMD), improves bone mineral density (BMD), and fibromyalgia.

Does IGF-1 cause hair loss?

In summary, regulation of human hair growth by androgen is probably mediated by IGF-1 in the dermal papilla. In male scalp, high levels of IGF-1 may increase the androgen receptor activity and dihydrotestosterone levels and these result in an increased propensity for baldness.

Which is better HGH or IGF-1?

HGH is generally considered to employ anti-insulin actions, whereas IGF-1 has insulin-like properties. By maintaining relatively low levels of IGF-1 and synergy between HGH and IGF-1 throughout your patients’ adult life, they may be able to live a healthy lifestyle and experience optimal aging.

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