Is pleomorphic adenoma malignant?

Is pleomorphic adenoma malignant or benign?

Pleomorphic adenomas are benign salivary gland tumors, which predominantly affect the superficial lobe of the parotid gland. The “pleomorphic” nature of the tumor can be explained on the basis of its epithelial and connective tissue origin. The tumor has a female predilection between 30–50 years of age.

Is pleomorphic adenoma premalignant?

Abstract : Atypical pleomorphic adenoma (PA)is a premalignant condition of PA, although its immunoreactivity for HER2/neu, which is a marker for carcinoma (Ca)ex PA, is still unclear.

What is pleomorphic adenoma?

Pleomorphic adenoma is a benign salivary gland tumor that exhibits wide cytomorphologic and architectural diversity. The tumor has the following 3 components: An epithelial cell component. A myoepithelial cell component. A stromal (mesenchymal) component.

Should pleomorphic adenoma be removed?

Due to the aggressive nature of this tumor, and poor cure rate, it is advised that benign Pleomorphic adenomas be removed to prevent transformation into this cancer.

What causes a pleomorphic adenoma?

The causes of pleomorphic adenomas are still unknown and the risk factors have not been fully ascertained yet. In addition to age, risk factors may be related to smoking habits, alcohol abuse, a diet rich in cholesterol and previous radiation therapy treatments in the face and neck regions.

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What percentage of pleomorphic adenomas become malignant?

Pleomorphic adenomas harbor a small risk of malignant transformation. The malignant potential is proportional to the time the lesion is in situ (1.5% in the first five years, 9.5% after 15 years).

Can a pleomorphic adenoma come back?

Multiple or bilateral pleomorphic adenomas are rare [3, 4, 5]. After surgical resection, up to 43% of patients are at risk for recurrence, even as long as 45 years after the initial surgery.

Does a pleomorphic adenoma cause pain?

Pleomorphic adenoma typically presents as a slow-growing, painless, firm mass and is only occasionally associated with facial palsy or pain.

What are adenocarcinoma cells?

Cancer that begins in glandular (secretory) cells. Glandular cells are found in tissue that lines certain internal organs and makes and releases substances in the body, such as mucus, digestive juices, or other fluids. Most cancers of the breast, pancreas, lung, prostate, and colon are adenocarcinomas.

What does pleomorphic mean?

Listen to pronunciation. (PLEE-oh-MOR-fik) Occurring in various distinct forms. In terms of cells, having variation in the size and shape of cells or their nuclei.

Are pleomorphic adenomas genetic?

Overall, pleomorphic adenomas are very treatable when caught early and do not recur. There does seem to be a genetic link between pleomorphic adenomas and a few genes, like the PLAG1 gene.