Is melanoma a hormone dependent cancer or a hormone responsive cancer?


Is melanoma hormone driven?

Although melanoma is classically considered a non-hormone-related cancer, increasing evidence support a direct correlation between sex hormones (estrogens, in particular) and melanoma.

What are hormone dependent cancers?

A hormone-sensitive cancer, or hormone-dependent cancer, is a type of cancer that is dependent on a hormone for growth and/or survival. Examples include breast cancer, which is dependent on estrogens like estradiol, and prostate cancer, which is dependent on androgens like testosterone.

What type of cancer does melanoma belong?

Melanoma is a type of skin cancer that develops when melanocytes (the cells that give the skin its tan or brown color) start to grow out of control.

Does estrogen feed melanoma?

Melanoma and benign nevi have been shown to express estrogen-binding receptors, and sex hormones can be associated with increased melanocyte proliferation, which is associated with early-stage melanoma. Both of these observations suggest a link between sex hormones and melanoma development.

Can melanoma cause hormone imbalance?

Generally, melanoma is not labeled as a hormone-dependent cancer because of the belief that UV rays from the Sun is the major cause for melanoma [15].

Does testosterone affect melanoma?

The results show that for men, higher levels of testosterone, whether freely or in total, were associated with a greater risk of developing malignant melanoma. Indeed, each 50 pmol/L increase in free testosterone was found to raise the chance of developing this cancer by 35%.

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Is hormone a carcinogen?

Hormones are therefore capable of acting as powerful carcinogens, and are considered a ‘complete carcinogen‘ because of their ability to both initiate and promote the development of cancers. Hormones have been implicated in the genesis of breast, prostate, uterine, ovarian, testicular, thyroid and bone cancers.

Can hormone imbalance cause tumors?

Understand that a hormone imbalance is a risk factor for cancer and not a diagnosis. There are some causes of excess hormone that are out of your control, such as an early start to menstruation. Don’t worry about that. Tell your doctor, but move on and focus on what you can control.

Can you have melanoma for years and not know?

How long can you have melanoma and not know it? It depends on the type of melanoma. For example, nodular melanoma grows rapidly over a matter of weeks, while a radial melanoma can slowly spread over the span of a decade. Like a cavity, a melanoma may grow for years before producing any significant symptoms.

Where does melanoma usually spread to first?

Normally, the first place a melanoma tumor metastasizes to is the lymph nodes, by literally draining melanoma cells into the lymphatic fluid, which carries the melanoma cells through the lymphatic channels to the nearest lymph node basin.