How do you treat a giant cell tumor of the tendon sheath?
Marginal excision of giant cell tumor (GCT) of the tendon sheath (see the images below) has typically been the treatment of choice; systemic pharmacotherapy (pexidartinib) is now available (see Medical Therapy).
Is giant cell tumor fatal?
Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations.
Can a giant cell tumor be cancerous?
What is a giant cell tumor? Giant cell tumor of bone is a rare, aggressive non-cancerous tumor. It generally happens in adults between ages 20 and 40 when skeletal bone growth is complete. It usually develops near a joint at the end of the bone.
What causes giant cell Tumour?
What causes giant cell tumors? The exact cause of giant cell tumors is not known. But in some cases, they have been linked to Paget disease of bone. This is a long-term (chronic) bone disorder in which bones become enlarged and misshapen.
How often do giant cell tumors come back?
Clinically, GCT presents as a benign but often aggressive lesion with a tendency toward local recurrence. Depending on the type of treatment and the local presentation of the tumor, recurrence rates range from 0% to 65% (Table 1) [1, 3, 5, 6, 15, 20, 25, 26, 29, 31, 37, 38, 40, 43, 50].
What does giant cell mean?
Giant cells are formed by fusion of various cells such as macrophage, epithelioid cells, monocytes, etc., These are multi-nucleated, large in size, and most of the times present at the site of chronic inflammation and other granulomatous conditions.
What is malignant giant cell tumor?
The term malignant giant cell tumor has been used in soft tissues to describe a tumor with a mixture of benign giant cells and malignant mononuclear cells. This has been considered to be a type of malignant fibrous histiocytoma and probably not related to true benign giant cell tumors of soft tissue.
What is giant cell granuloma?
Central giant cell granuloma (CGCG) is an uncommon, benign but aggressive osteolytic neoplasm of the craniomaxillofacial region, histologically characterized by an abundance of evenly distributed multinucleated giant cells within a sea of spindle-shaped mesenchymal stromal cells, scattered throughout the fibrovascular …
Do benign tumors grow fast?
Benign tumors tend to grow slowly and have distinct borders. Benign tumors are not usually problematic. However, they can become large and compress structures nearby, causing pain or other medical complications.