How does chemotherapy affect the spleen?

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Can chemo enlarge your spleen?

In patients with CRCLM, the presence of liver metastases and chemotherapy are associated with higher splenic volume. Percent splenic volume increase after 6 months of chemotherapy can aid preoperative risk stratification, as it was an independent predictor of major postoperative complications.

What happens when cancer spreads to the spleen?

Cancer that starts in or spreads to the spleen can cause it to enlarge. If this happens, you might: feel full after eating. have pain in the upper-left side of your belly.

Can chemo cause a ruptured spleen?

Surprisingly, splenic rupture can occur after initiation of chemotherapy even in the setting of a normal spleen, which is supposed to be due to release of lytic substance from the dying cells [9]. The situation usually presents with severe left-sided abdominal pain, and in most of the cases haemodynamic instability.

What foods to avoid if you have an enlarged spleen?

It is important to avoid foods that are “damp”: alcohol, fat, fast sugars and excessive quantities of dairy products — for example, “fromage blanc,” which has a moisture content of 80%. The spleen is sensitive to erratic eating habits and can be weakened by skipping breakfast, copious or late dinners, and snacking.

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Can a cancerous spleen be removed?

A splenectomy is a surgical procedure in which all or part of the spleen is removed. A splenectomy can be done to treat both benign and cancerous conditions such as Hodgkin’s and non-Hodgkin’s lymphoma and some types of leukemia, such as chronic lymphocytic leukemia and hairy cell leukemia.

How serious is cancer of the spleen?

Complications of untreated spleen cancer can be serious, even life threatening in some cases. You can help minimize your risk of serious complications by following the treatment plan you and your health care professional design specifically for you.

What cancers affect the spleen?

Spleen cancers are typically secondary, meaning that they originate elsewhere and then spread to the spleen. The most common causes of spleen cancer are lymphomas and leukemias. On occasion, other cancers, such as breast, lung, stomach, pancreatic, liver, or colon, are the source of the malignancy.

What cancers metastasize to the spleen?

The main sites of primary tumors that metastasize to spleen are lung, colon and rectum, ovary, malignant melanoma or breast [3, 5]. Secondary splenic tumors from colorectal cancers occured mostly at an advanced stage with other organs involved [6, 7].

Can GCSF cause splenic rupture?

Granulocyte colony-stimulating factor (G-CSF) is commonly used for prevention and treatment of febrile neutropenia among solid tumor patients. It is considered an effective and relatively safe supportive care medication; however, it can cause rare and serious side effects such as spleen rupture or infarction.

Can u live without a spleen?

Some people are born without a spleen or need to have it removed because of illness or injury. The spleen is a fist-sized organ in the upper left side of your abdomen, next to your stomach and behind your left ribs. It’s an important part of your immune system, but you can survive without it.

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How do you know if you have a bad spleen?

Symptoms you may experience with an enlarged spleen include:

  1. pressure or pain in the left upper part of your abdomen (near the stomach),
  2. feeling full without eating a large meal,
  3. or pain your left shoulder blade or shoulder area when taking a deep breath.

Is water good for spleen?

Drinking cold water hurts your spleen and stomach

In traditional Chinese medicine, cold water and iced drinks weaken the spleen and stomach, interfering with their normal functions. The spleen is the major organ for the formation and circulation of “Qi” to distribute blood and nutrients throughout the human body.