Frequent question: Which chemo drug is an irritant with vesicant properties?

Is oxaliplatin a vesicant or irritant?

Oxaliplatin is a novel class of platinum chermotherapeutic agent used in refractory adenocarcinoma. It has previously been regarded as a non-vesicant, and as such was considered safe to administer through peripheral veins.

Which of the following is an irritant with vesicant properties?

Drugs that are classified as irritants with vesicant properties include docetaxel, liposomal doxorubicin, melphalan, mitozantrone, oxaliplatin, paclitaxel and nab-paclitaxel.

What chemo is vesicant?

Vesicant chemotherapy agents include: Dactinomycin, daunorubicin, doxorubicin, epirubicin, idarubicin, mechlorethamine, mitomycin, mitoxantrone, paclitaxel, streptozocin, tenoposide, vinblastine, vincristine, vinorelbine.

Is Methotrexate a vesicant or irritant?

Extravasation management table

Drug name Class/clinical procedure Antidote
Methotrexate Non-irritant (neutral) Not indicated
Mitomycin Vesicant Dimethyl sulfoxide (DMSO 99% solution)
Mitozantrone Irritant with vesicant properties No recommended antidote
Nivolumab Non-irritant (neutral) Not indicated

Is Dactinomycin an irritant?

Dactinomycin should be administered only into a vein. However, it may leak into surrounding tissue causing severe irritation or damage.

What is the antidote for anthracycline extravasation?

Preclinical and clinical studies are leading to the clinical implementation of dexrazoxane as the first and only proven antidote in anthracycline extravasation. In two multicenter studies dexrazoxane has proven to be highly effective in preventing skin necrosis and ulceration.

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How do you manage infiltration?

Some possible treatments are:

  1. Elevate the site as much as possible to help reduce swelling.
  2. Apply a warm or cold compress (depending on the fluid) for 30 minutes every 2-3 hours to help reduce swelling and discomfort.
  3. Medication-If recommended, medicine for extravasations is given within 24 hours for best effect.

What is a vesicant medication?

Vesicants: Drugs that can result in tissue necrosis or formation of blisters when accidentally infused into tissue surrounding a vein[14]. They include Actinomycin D, Dactinomycin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitomycin C, Vinblastine, Vindesine, Vincristine, and Vinorelbine.

What is the best method of extravasation prevention?

Apply either ice packs or warm compresses to the affected area, depending on the type of vesicant. For most extravasations, apply ice for 20 minutes four to six times a day for 24 to 48 hours. However, treat extravasations from vinca alkaloids, epipodophyllotoxins, and vasoconstricting drugs with heat.

How long does it take for veins to return to normal after chemo?

Blown veins require medical treatment, but they do not usually result in long-term damage to the vein and generally heal in 10–12 days.

Why does chemo cause arm pain?

Certain types of chemotherapy, such as paclitaxel, may also cause myalgias. Other possible causes of myalgias are: Infections – Infection in the blood, which produces a fever, may cause muscle aches. You may also have an infection or inflammation in one of your muscle groups, that may have caused pain.

What is a risk factor for venous irritation?

Various drugs can induce venous irritation when administered via peripheral venous infusion, and the osmolality and pH of the solution are reported to influence the likelihood of venous irritation [1]. Moreover, reaction to the drug itself is considered a significant factor in the occurrence of venous irritation.

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