When is docetaxel used in prostate cancer?
Docetaxel is used as a chemotherapy drug and is prescribed in cases of hormone-refractory metastatic prostate cancer, among many other cancers. It is used with the purpose of blocking the growth of the tumor, as it acts on the cancerous cells, preventing them from separating into two new cells.
Does Chemo work on prostate cancer?
Chemotherapy refers to any type of therapy that uses chemicals to kill or halt the growth of cancer cells. While chemotherapy is unlikely to cure prostate cancer, it may provide some benefits to patients.
How long does docetaxel work for?
The median overall survival (OS) was 81 months with docetaxel plus standard of care (hormonal therapy with or without radiotherapy) versus 71 months with standard of care alone (0.78; 95% CI, 0.66-0·93;P= . 006).
How effective is docetaxel?
Doses of 100 mg/m2 of docetaxel, administered over 1 hour every 3 weeks, produced an overall response rate of 50% (range, 41% to 58%) in 129 evaluable patients, with a median duration of 6 months (range, 2 to 17 months).
Can you live 10 years with metastatic prostate cancer?
Of the 794 evaluable patients, 77% lived < 5 years, 16% lived 5 up to 10 years, and 7% lived > or = 10 years. Factors predicting a statistical significant association with longer survival (P < 0.05) included minimal disease, better PS, no bone pain, lower Gleason score, and lower PSA level.
Is docetaxel a strong chemo?
Because the active ingredient, docetaxel, is a strong chemotherapy drug, it also has a long list of side effects. Most of them are typical for drugs in this class, such as nausea, vomiting and temporary alopecia (hair loss).
What is the life expectancy of someone with metastatic prostate cancer?
Fewer men (about 7 %) have more advanced prostate cancer at the time of diagnosis. Once prostate cancer has spread beyond the prostate, survival rates fall. For men with distant spread (metastasis) of prostate cancer, about one-third will survive for five years after diagnosis.
Does anyone survive metastatic prostate cancer?
Prostate cancer diagnosed in the advanced stages is difficult to cure, although many people live for many years with effective treatment. The survival rate in most people with advanced prostate cancer (Stage IV) is 30 percent at the fifth year of diagnosis.
Is chemo a last resort?
“Cancer chemotherapy has evolved from a last resort 60 years ago to treatment that now can cure patients or markedly prolong their lives, often with far fewer side effects than with the original drugs decades ago,” says Joseph Paul Eder, MD, a Yale Medicine medical oncologist.
What is the most common side effect of docetaxel?
The most common adverse reactions across all TAXOTERE indications are infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin …
How does docetaxel make you feel?
People having docetaxel may have pain, numbness or tingling in their hands and feet. This is due to the effect of docetaxel on the nerves and is known as peripheral neuropathy.
Can you lose hair with docetaxel?
You usually lose all the hair from your head. You may also lose your eyelashes and eyebrows, as well as other body hair. Hair loss usually starts after your first or second treatment.